Isaac Melville McCune (August 27, 1884 – October 15, 1959) was a provincial politician from Alberta, Canada.

He served as a member of the Legislative Assembly of Alberta from 1935 to 1940 sitting with the Social Credit caucus in government.

McCune ran for a seat to the Alberta Legislature as a Social Credit candidate in the electoral district of Gleichen in the 1935 Alberta general election.

He defeated incumbent John Buckley and two other candidates by a wide margin to pick up the seat for his party.

[3] McCune ran for a second term in the 1940 Alberta general election.