Isaac Mpofu (born 20 August 1988) is a Zimbabwean long-distance runner who specialises in the marathon.

[1] He represented Zimbabwe at the 2019 World Athletics Championships, competing in the men's marathon.

[2] He finished in 52nd place.

[2] He also represented Zimbabwe at the 2022 World Athletics Championships, in the men's marathon where he finished in 10th place.

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