Isaac N. McComb (December 11, 1850 – January 27, 1938) was an American physician and politician.
McComb also served on the Calumet County, Wisconsin Board of Supervisors.
In 1901, McComb served in the Wisconsin State Assembly and was a Democrat.
He also served as a jury commissioner and pension examiner.
This article about a Democratic Party member of the Wisconsin State Assembly is a stub.