The Isaac Stern House was a mansion at 858 Fifth Avenue on the Upper East Side of Manhattan in New York City.

[1] The home was designed by the firm of Schickel & Ditmars, and it was constructed for the entrepreneur Isaac Stern (d. 1910).

He was one of the founders of the Stern Brothers department store and was the father of Robert B. Stearns, who became a prominent financier and co-founded Bear Stearns in 1923.

The mansion was later owned by businessman Thomas Fortune Ryan.

This article about a building or structure in Manhattan is a stub.