Isaac Lobe Straus (March 24, 1871 – February 4, 1946) was an American politician and lawyer from Maryland.

He attended Baltimore City College and graduated from Johns Hopkins University in 1890.

[2] Straus served as general counsel to the Board of Supervisors of Elections for Baltimore from 1900 to 1901.

He served as special counsel for the state of Maryland relating to the Baltimore and Ohio Railroad.

Straus served in the Maryland House of Delegates, representing Baltimore, in 1902.