Isaac William Wiley (simplified Chinese: 怀礼; traditional Chinese: 懷禮; Pinyin: Huáilǐ; Foochow Romanized: Huài-lā̤; 29 March 1825 – 22 November 1884) was an American who distinguished himself as a physician, a Methodist missionary to China, a pastor, as the president of a seminary, as an editor, and as a bishop of the Methodist Episcopal Church, elected in 1872.

Isaac had been preparing to enter the sophomore class at Dickinson College, but the affection of his throat being considered permanent, he commenced the study of medicine, instead.

Dr. Isaac Wiley commenced the practice of medicine in Western Pennsylvania, subsequently moving to Pottsville in 1849.

Shortly thereafter, at the request of Dr. Durbin, Isaac agreed to go as a medical missionary to Fuzhou, China.

Dr. Isaac William Wiley was elected to the episcopacy of the Methodist Episcopal Church by the General Conference of 1872.

Wiley College was founded by the Methodist Episcopal Church in 1873 and chartered by the Freedman's Aid Society of the M.E.

Church in 1882 for the purpose of providing education to the "newly freed men" (following emancipation and the American Civil War), preparing them for a new life.