Isaac ben Moses Abulafia (1824-1910) was a rabbi and halakhist.

His authoritarian attitude and his habit of making independent halakhic decisions roused the opposition of the other rabbis and of the communal leaders of Damascus, who united in an attempt to remove him from his position.

In 1896 they turned to Moses ha-Levi, the Hakham Bashi, in Constantinople, who acceded to their request by appointing Solomon Eliezer Alfandari rabbi of Damascus.

Toward the end of his life Abulafia acted as rabbi in Tyre.

An outstanding halakhic scholar, his responsa Penei Yizhak were published in six volumes (1871-1906).