Isabel is a city in Barber County, Kansas, United States.

[5] According to the United States Census Bureau, the city has a total area of 0.25 square miles (0.65 km2), all of it land.

[6] Isabel is located on the north county line, on the Mulvane extension of the Santa Fe, in Valley township.

[7] The 2020 United States census counted 68 people, 23 households, and 17 families in Isabel.

There were 38 housing units at an average density of 152.0 per square mile (58.7/km2).

26.1% of households consisted of individuals and 8.7% had someone living alone who was 65 years of age or older.

[17][18] At the 2010 census there were 90 people in 40 households, including 23 families, in the city.

There were 47 housing units at an average density of 188.0 per square mile (72.6/km2).

There were 53 housing units at an average density of 211.0 per square mile (81.5/km2).

There were 18.5% of families and 17.0% of the population living below the poverty line, including 36.4% of under eighteens and 6.9% of those over 64.