Isabel McIsaac (1858 – September 21, 1914) was the third superintendent of the United States Army Nurse Corps.

In 1898, she became president of the American Society of Superintendents of Training Schools for Nurses.

The year before, she had become president of the American Journal of Nursing Company.

She resigned from being superintendent for health reasons, with the resignation set for October 1, 1914, but McIsaac died on September 21, 1914, two weeks before the set date.

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