Her name is mentioned in the letters of Francisco Cervantes de Salazar and Bernal Díaz del Castillo.
She had the idea of creating an established group of nurses that would accompany the soldiers consistently.
She trained and coordinated young women, from both Spain and the allied native nations, that desired to take part in the conquest to treat war wounds and form a corps of nurses that followed the conquerors and intervened after, or even during, battle, to assist the wounded.
When the conquest was over, and after several of her companions and former patients acted as witnesses, the Spanish Crown granted her the title of "Honorary Doctor", a profession reserved only for men at the time, and granted her permission to freely exercise medicine in the lands of Nueva España.
This makes Isabel one of the first recognized female doctors in western history.