Isabel Stuart (28 August 1676 – 2 March 1681), also called Isobel and Isabella,[1] was a daughter of the future King James II of England and his second wife, Mary of Modena.

She was moved down a place upon the birth of her brother Charles Stuart, Duke of Cambridge; however, he died of smallpox after living only for a month, so Isabel was promoted back up to fourth in line.

[4] They feared that the King's eldest illegitimate son, James Scott, 1st Duke of Monmouth and commander of England's armed forces, might usurp the crown if Charles died in their absence.

[8] The couple were recalled to London in February 1680, only to return again to Edinburgh that autumn; this time they went on a more honourable footing: James was created King's Commissioner to Scotland.

[10][11] Lady Isabel, thus far the only one of Mary's children to survive infancy, died of natural causes in March 1681, at age 4 years, 6 months, at St James's Palace, the place of her birth.