Isabel Withers (January 20, 1896 – September 3, 1968) was an American actress, who worked in theatre, film, and television.

She played the leading role in The Tailor Made Man after a season in stock theatre in Utica, New York.

George M. Cohan selected Withers for the lead feminine role, with Lowell Sherman, in the Chicago company of The Tavern.

Henry Duffy wired her to come to San Francisco, California, to do Kempy just as she was on her way to visit her mother in Los Angeles.

Withers accumulated ninety-two screen and television credits, beginning with a role in the movie The Hot Spot (1931).