The third child of four, Isabella's older sister Cecilia was one of the greatest English sopranos of the 18th century and the wife of composer Thomas Arne.
Her younger sister Esther was a successful contralto and her older brother Charles was a clerk at the Royal Treasury.
This was followed by several concert appearances and she did not return to the stage again until 1737 when she sang the heroine Margery in John Frederick Lampe’s burlesque opera The Dragon of Wantley.
[2] In 1748 the Lampes went to Dublin and Isabella appeared for two seasons at the Smock Alley Theatre, including portraying the role of Coridon in Handel's Acis and Galatea.
[2] Following the death of her father in 1758, Isabella's son Charles John Frederick Lampe took over his grandfather's post as organist at All Hallows, Barking-by-the-Tower.