The origin of the college was in a school for girls opened by Isabella Thoburn on 18 April 1870 in one room in Aminabad bazaar of Lucknow.

By 1871, the school had expanded and moved to occupy a house named Lal Bagh, which had been lived in by the treasurer of the last Nawab of Awadh.

[1][2] On 12 July 1886 Miss Thoburn's school was renamed as the Lucknow Women's College and began to teach Fine Arts classes under the supervision of the University of Calcutta.

The buildings it has developed on the Chand Bagh campus since the 1920s include student hostels, lecture rooms, laboratories, a library, a college chapel and an auditorium.

[citation needed] On 12 April 2012, the Government of India issued a new five rupee postage stamp illustrating the college.

Incorporating religious studies in the education system helps guide students toward spirituality, which is associated with qualities like love, honesty, and humility.