She married Charles D. Blaney (1854–1923) on September 6, 1877, in Evanston,[1] and in 1883 they moved to a large ranch in the Santa Clara Valley of California.

[6] Isabella Blaney was said to have "traveled extensively, is interested in foreign missions and is the principal promoter, if not the founder, of a medical hospital in Northern China.

[8] In 1910 she supervised and financed a house-to-house canvass of the Santa Clara Valley on behalf of women's suffrage in a California special election on October 10, 1911.

[17] As a member of the Progressive Party, Blaney supported John M. Eshleman in his successful 1914 bid for California lieutenant governor.

[20][21][22][23] The Blaney home in Saratoga, California, which cost $300,000 to build on the crest of a knoll and held a theater and ballroom, attracted newspaper attention when it was completed in 1918.

[24][25] The residence was the site of three one-act dramas dealing with the lives of American Indians, written by Hartley Alexander and directed by Marion Craig Wentworth in August 1927.