Isabella d'Este (3 October 1635 – 21 August 1666) was Duchess of Parma, and second wife of Duke Ranuccio II Farnese.

Later focus was on arranging a match for Isabella with one of the German princes who were allied with France in the League of the Rhine.

[1] After the death of his first wife Marguerite Yolande of Savoy, Ranuccio II married in 1663 his cousin Isabella.

Only the youngest Odoardo, would have issue; he was the father of Elisabeth Farnese, queen of Spain and ancestor of most modern royalty.

But the birth of her son proved fatal to Isabella, who died of complications nine days later on 21 August, at Colorno.