In 1513, an engagement contract between Orsini and Pier Luigi Farnese was drawn up, and in 1519 the wedding was celebrated at Valentano.

She was described as a sensible person capable of making important decisions when necessary, close to the Pope and the interests of her sons.

She lived a retired life, but was always actively engaged in maintaining the political interest of her sons.

[1] Her regency ended when she was informed of the death of her son Orazio in 1553, and she departed for Parma, where she settled for the rest of her life.

She was buried at the Farnese crypt at the Sanctuary of Santa Maria della Steccata, Parma.