Isabella's older half sisters include, Constance, Queen of Sicily, Joanna, Countess of Ampurias and Eleanor, Queen of Castile.

The county of Urgell was dissolved in 1413, following her husband's revolt against the new King Ferdinand I of Aragon who had been chosen to succeed to the throne of Aragon in 1412 despite James having had the stronger claim as the closest legitimate agnate to the Royal House of Barcelona.

Earlier, King Ferdinand had offered James 150,000 florins, the title of Duke of Montblanc, and proposed an alliance between his son Henry and their eldest daughter, Isabella, but James had refused Ferdinand's offer on the advice of his mother.

In addition to the loss of his title and assets, James was later tried, condemned, and sentenced to life imprisonment.

Their eldest surviving daughter, Isabella, became Countess of Urgell as well as Duchess consort of Coimbra.