The queen consort of Frederick I of Austria, she was a member of the House of Barcelona.

Negotiations for the marriage broke down in the face of Armenian opposition to increased close ties with the Catholic western powers.

With her marriage, Isabel became one of two Queens of Germany with Beatrix von Silesia-Glogau, wife of Louis IV.

On 5 September 1325, Frederick I and Louis IV resolved their conflict by agreeing to serve as co-rulers.

However Frederick soon became the junior co-ruler and retired to Austria until his death on 13 January 1330.