Isabelle Frances Daniels (later Holston; July 31, 1937 – September 8, 2017) was an American sprinter.

Daniels attended Tennessee State University, where she was part of their AAU champion relay team for 5 years.

She competed for the United States in the 1956 Summer Olympics held in Melbourne, Australia, where she won the bronze medal in the 4×100 metres with her teammates Mae Faggs, Margaret Matthews and Wilma Rudolph, in a race where all three teams beat the existing world record.

[4] In 1992 she was honored as the All-State Role Model; a documentary on her life was produced and broadcast in the halftime of the Georgia high school all-stars basketball game.

In March 2006 she was inducted into the Hall of Fame of the Bob Hayes Invitational Track Meet in Jacksonville, Florida.