[1][2] His first teacher was his father, Avraham ben Shabtai Sheftel Horowitz, a notable scholar and author, and a disciple of Moses Isserles (Rema).
In 1590, in Lublin, he participated in a meeting of the Council of Four Lands, and his signature appears on a decree that condemns the purchase of rabbinic positions.
In 1621, after the death of his wife, he moved to Israel, was appointed rabbi of the Ashkenazi community in Jerusalem, and married Hava, daughter of Eleazer.
After 1626, Horowitz moved to Safed, erstwhile home of Kabbalah, and later died in Tiberias on March 24, 1630 (Nisan 11, 5390 on the Hebrew calendar).
[6] His most important work Shenei Luḥot HaBerit (Hebrew: שני לוחות הברית, Two Tablets of the Covenant, abbreviated Shelah של"ה), is an encyclopedic compilation of ritual, ethics, and mysticism.