Isaiah Quinby Lukens (24 August 1779 – 12 November 1846) was an American clockmaker, gunsmith, machinist, and inventor from southeastern Pennsylvania.

According to George Escol Sellers, whose father was close friends with Lukens, "he called [Saxton] his pupil, and he did honor to his preceptor".

[7] The family was descended from Jan Lucken, who immigrated to the Pennsylvania colony in October 1683, with Daniel Pastorius, and was one of the original settlers of Germantown.

[8][2][9] Lukens grew up on his family's farm in Horsham, Montgomery County, Pennsylvania, and learned from his father to construct clocks and watches.

[2] George Escol Sellers wrote that he was "naturally of a social disposition, although an impediment in his speech made him appear shy and diffident in ladies' society.