Isaiah McGuire (born July 27, 2001) is an American professional football defensive end for the Cleveland Browns of the National Football League (NFL).
McGuire attended Union High School in Tulsa, Oklahoma.
He committed to the University of Missouri to play college football.
[1] As a true freshman at Missouri in 2019, McGuire played in six games and had four tackles.
He started all 13 games his junior year in 2021, recording 55 tackles and six sacks.