Isawa-Onsen Station (石和温泉駅, Isawa-Onsen-eki) is a railway station of the Chūō Main Line, East Japan Railway Company (JR East) in the Isawa-Matsumoto neighborhood of the city of Fuefuki, Yamanashi Prefecture, Japan.

The station has a Midori no Madoguchi staffed ticket office.

The JGR became the JNR (Japanese National Railways) after the end of World War II.

With the dissolution and privatization of the JNR on April 1, 1987, the station came under the joint control of the East Japan Railway Company and the Japan Freight Railway Company.

Automated turnstiles using the Suica IC Card system came into operation from October 16, 2004.