Isesaki Station is a station on the JR East Ryōmō Line, and is located 69.1 km (42.9 mi) from the terminus of the line at Oyama, and 22.6 km (14.0 mi) from Takasaki.

[3] Isesaki Station was opened on 20 November 1889 for Ryōmō Line service.

[5] The station section servicing the Ryōmō Line was absorbed into the JR East network upon the privatization of the Japanese National Railways (JNR) on 1 April 1987.

[6] In May 2010, the construction work to elevate the Ryōmō Line platforms in Isesaki Station was completed.

The Midori no Madoguchi ticket office was closed on 30 November 2021[9].In fiscal 2021, the Tōbu station was used by an average of 5,612 passengers daily.