Shin-Isesaki Station (新伊勢崎駅, Shin-Isesaki-eki) is a passenger railway station in the city of Isesaki, Gunma, Japan, operated by the private railway operator Tōbu Railway.

Shin-Isesaki Station is served by the Tōbu Isesaki Line, and is located 113.3 kilometers from the terminus of the line at Asakusa in Tokyo.

Shin-Isesaki Station has two elevated side platforms, with the station building underneath.

[1] From 17 March 2012, station numbering was introduced on all Tōbu lines, with Shin-Isesaki Station becoming "TI-24".

[2] New elevated platforms and a new station building were brought into use from 19 October 2013.