He succeeded his father, Sarduri I, who moved the capital to Tushpa (Van).

[1] Ishpuini conquered the Mannaean city of Musasir, which was then made the religious center of the empire.

The main temple for the war god Haldi was in Musasir.

[citation needed] Ishpuini was succeeded by his son, Menua.

He captured the city of Trtimi in the territory of the country of Urme.