Isili, Ìsili in sardinian language, is a comune (municipality) in the province of South Sardinia, southern Sardinia, Italy, located about 60 kilometres (37 mi) north of Cagliari in the Sarcidano traditional region.

Isili borders the following municipalities: Gergei, Gesturi, Laconi, Nuragus, Nurallao, Nurri, Serri, Villanova Tulo.

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