[2] Dick King went to Natal in 1828 and was awarded a large stretch of land between the Umlaas/uMlaza and Mbokodweni rivers at present-day Isipingo Rail, an area where he had already acquired some farmland and built himself a house.

In May 1853, the Natal Mercury reported that Mr Jeffels of Isipingo ventured into sugarcane cultivation and is erecting buildings for sugar manufacturing.

The indenture system was used from 1860 to supply cheap Indian labour to the sugar cane farms in Isipingo and the surrounding areas.

Between 1893 and the outbreak of the Second Boer War, the South Coast Line was extended 44 km (27 mi) from Isipingo Rail to Park Rynie.

It is bordered to the north by the defunct Durban International Airport, to the west by Umlazi, and to the south by Athlone Park and Umbogintwini.

The adjoining major industrial area of Prospecton is the location of one of South Africa's largest automobile assembly plants, that of Toyota.

The R102 (South Coast Road) runs parallel to the N2 and links Isipingo to Reunion and Athlone Park, providing access to the N2 at Prospecton.