Isis River is a locality in the Bundaberg Region, Queensland, Australia.

[1] The Isis River (from which the locality presumably takes its name) flows through the locality entering from the south-east (South Isis) and exiting to the north-east (Buxton/Cherwell).

[3] The Bruce Highway passes through the locality from the west (South Isis/Horton) to the east (Cherwell).

[3] In the south of the locality is the Wongi State Forest which extends into neighbouring Kullogum and Duckinwalla.

[3] There is a small amount of cropping, most of the land is undeveloped native vegetation.