[3] The generic name, "Isisaurus," combines a reference to the Indian Statistical Institute (ISI) with the Greek "saurus," meaning "lizard."

It had a short, vertically directed neck and long forelimbs,[citation needed] making it considerably different from other sauropods.

[1] The site locality is Dongargaon Hill, which is in a Maastrichtian crevasse splay claystone in the Lameta Formation of India.

The holotype includes cervical, dorsal, sacral and caudal vertebrae, ribs, pelvis, scapula, coracoid, left forelimb and other bones.

In that matter, the cranium of Isisaurus resembles the skulls of Diplodocus and Apatosaurus (genera belonging to the Diplodocidae), but the bone modifications are different.

[8] While Isisaurus has consistently been considered to be a titanosaurian sauropod, its exact placement within this clade and its relationships with other titanosaurs has been controversial and problematic.

The cladogram from Rubilar-Rogers et al. (2021) is shown below:[12] Malawisaurus Baurutitan Rapetosaurus Arackar Isisaurus Tapuiasaurus Alamosaurus Opisthocoelicaudia Saltasaurinae Fungus in coprolites believed to have been voided by Isisaurus indicate that it ate leaves from several species of tree, since these fungi are known to be pathogens which infect tree leaves.