Punji Khatun the mother of Ismail hatched a counter-plot and Kamal Khan was stabbed to death in the royal palace.
Later Kasmim Barid with the Muslim kings of Ahmednagar, Golconda and Berar invaded Bijapur, however, Ismail Adil Shah was able to defend himself and his territory.
Ismail ruled peacefully only before waging a war against Nizam Shah of Ahmednagar, who did not aid Ashad Khan during his conquest against Timraj of Vijayanagar.
Nizam Shah was unhappy because he was promised the fort of Sholapur as dowry when he married Ismail's sister Mariam, which was never handed over.
After his death his son Mallu, the eldest was crowned however he was deposed through the efforts of his grandmother and General Asad Khan.