Produced in small numbers for one-off aircraft, including the Ambrosini SAI.107 and Caproni Vizzola F.5 Gamma fighter trainer prototypes, it was developed into the more powerful and more numerous Delta.

[1] Isotta Fraschini produced the Gamma in small numbers during World War II at a rating of about 500 hp (373 kW).

The more powerful Delta was developed as a larger complement to the Gamma.

The larger engines shared with the Gamma a problem cooling the rearmost cylinders which impeded development.

[3] In 1942, there was speculation in the UK about a powerful Italian engine called the Isotta Fraschini Gamma that produced 1,700 hp (1,268 kW) at 2200 rpm for take-off and had a displacement of 55.562 L (3,391 in3) with a bore of 195 mm (7.7 in) and stroke of 192.5 mm (7.58 in).