Her professional boxing debut came on February 14, 1995, in Louisiana, when she lost to future world champion Deirdre Gogarty by a knockout in three rounds.
[5] On November 2, she acquired her first victory, a six-round decision win, over Melinda Robinson, another future world champion, in Austin, Texas.
Girgrah then faced Christy Martin on a pay per view televised match that formed part of an undercard that included the Trinidad-Waters and López-Sánchez bouts.
Girgrah lost to Martin on points over eight rounds, but her name's stock rose in defeat, as most boxing magazine writers agreed that she performed well against the defending WBC women's world champion.
Girgrah became the first Middle Eastern woman to be a world champion in boxing history when she knocked out Mullet in the fourth round, in a fight that was, once again, held in Atlantic City.
After a fourth win over Robinson, she met Snodene Blackeney on June 1, at Atlantic City, to unify her UBA title with the WIBF world championship.
But among the fighters she beat were Mexico's Laura Serrano, decisioned over eight rounds on April 18, 2003 in Lemoore, California, and Puerto Rico's Melissa Del Valle, outpointed over eight rounds on September 6 of that same year in Washington D.C. After the win against Del Valle, Girgrah fought Jo Wyman on December 13, for the IFBA's vacant world Jr. Lightweight title.
Contrary to common boxing practice, Girgrah won her second division world championship by going down in weight, when she outpointed Wyman over 10 rounds in Washington.