Serrano began boxing at the Universidad Nacional Autónoma de México in Mexico City, where she was studying to become a lawyer.

After a short appearance in two episodes of the Volver a empezar soap opera, she went to Las Vegas, and on a pay per view card she challenged Christy Martin for the world title.

She won by a knockout in seven rounds, in what was the first all women's boxing undercard held at the Aladdin Hotel & Casino in Las Vegas.

[1] Serrano was supposed to box on the Julio César Chávez-Miguel Ángel González Pay Per View event's undercard in Mexico City.

Serrano has won her last two world title defenses, both decisions, one in ten rounds in Las Vegas and another one, a six-round win in Phoenix.