The Israel Arts and Science Academy (Beit Hasefer Ha'tichon Hayisraeli Lemada'im Vela'omanuyot) was founded in September 1990 by Mary Jane and Robert H. Asher and Raphi Amram.
Students may major in either natural sciences, music, visual arts, or humanities, though they study most subjects (those which are not related to their area of interest) in mixed classes.
The students learn by the "Great books" curriculum, which emphasizes reading primary sources, group discussions, commentary, analysis and academic writing.
Since the 2012–2013 school year, students and teachers of the department hold a Book Club in which they read a literary work and conduct a meeting where they discuss and analyze the piece.
Notable alumni include the Israeli Arab journalist Sayed Kashua; composers Aviya Kopelman and Matti Kovler; historian Yair Mintzker; and Eran Shir, the founder of Dapper.
Inc. Saying that following Israel's actions in Gaza, "courageous civic activism" had become necessary, dozens of IASA graduates published a letter in December 2014 calling on Israelis to refuse serving in the IDF, become conscientious objectors and stop what they view as oppression of Palestinians.