Isshiki clan (一色氏, Isshiki-shi) is a Japanese kin group of the Sengoku period.

The Isshiki held prominent offices in the bureaucracy of the Ashikaga shogunate.

[1] The Isshiki were one of four clans with the right to be head (bettō) of the Samurai-dokoro or war department.

[3] Later, the Isshiki were military governors of the province of Tango since 1336.

[4] The family lost its domains during the wars of the Sengoku period.