The ship initially built for the Italian Navy and was named Perseo with a pennant of F 566.

The ship was laid down on 28 February 1977, was launched on 12 July 1978 by the shipyard Riva Trigoso and commissioned in the Italian Navy on 1 March 1980.

At the end of the decade the ship was then engaged in the Persian Gulf, during the Iran-Iraq conflict.

Sailing in hostile waters are very dangerous and the Italian motor ship Jolly Rubino, attacked by the Iranian, this prompted the Navy to send a contingent to the area, made up of frigates, logistic units and minesweepers engaged in escort operations on the ship merchant and landmine clearance.

On 30 September 2021, Bolognesi successfully test fired the Exocet MM40 Block 3 anti-ship missile for the first time since its introduction to Peruvian Navy in 2016.