San Giorgio was laid down on 27 May 1985 and launched on 21 February 1987 by Fincantieri at Riva Trigoso.

Starting from December 1992 the San Giorgio, San Marco and the men of the San Marco Battalion took part in Somalia in the Ibis I and Ibis II missions with the 24th Naval Group together with Vittorio Veneto, Vesuvius and Grecale and with the 25th Naval Group together with the Giuseppe Garibaldi, the Stromboli and Scirocco.

food intended for the non-combatant civilian population made available by the Ministry of Foreign Affairs, the Civil Protection, the Italian Red Cross and the United Nations World Food Program.

On 3 August 2016, in addition to fighting smugglers and human traffickers, they have received two additional tasks: the training of the Libyan Coast Guard, the Libyan Navy and the control of the arms embargo towards Libya in accordance with the resolutions of the UN Security Council.

[2] Rear Admiral Frumento replaced his Greek counterpart Theodoros Mikropoulos who had been in command since October 19, 2020.