Italo De Sanctis (1881–1943) was an Italian painter, known for his portraits.
In Spoltore, the young Italo met painter Francesco Paolo Michetti and the sculptor Costantino Barbella, friends of his father.
However, defeated in 1920, he moved to Rome to study medicine, but became attracted to painting and took courses in the Roman Academy of Fine Arts.
He returned to Spoltore where he was patronized as a portrait artist, as well as painting rural genre scenes.
He was visited by many artists he had befriended over the years, including Tommaso Cascella, Giuseppe D’Albenzio, Leopoldo Dell’Elce, Giuseppe Misticoni (one of his pupils), and Pasquale De Antonis.