Following the emancipation of the municipality that year, the first Mayor, Victorio Eugenio Deliberato, began a campaign of industrial development that had great geographic and economic impact on Itaquaquecetuba in the decades to come.

[6][7] Today, Itaquaquecetuba is one of the 10 best Brazilian cities who had significant advances in challenges against inequality in the last 20 years, and has the second-best GDP in the region.

[9] The origin of the city dates back to Itaquaquecetuba of the twelve villages founded by the Jesuit priest José de Anchieta, in his long stay in Brazil.

Its creation is due to the then president of the province, Bernardo José Pinto Gavião Peixoto, named village of Nossa Senhora da Ajuda, on September 7, 1560, being established in the River Tietê, to catechize the guaianases.

Local bus service is provided by Expresso Planalto and Intercity buses are also available connecting the city to Poá, Mogi das Cruzes, Guarulhos, Arujá, Santa Isabel, Ferraz de Vasconcelos, Suzano and São Paulo.