DL&W ceased passenger operations in 1942, and Greyhound Bus Lines acquired the station in 1967.

[1][2] The station building accommodates waiting area with seats, ticketing and package express office, and restrooms.

Buses are now boarding downtown (at 131 East Green Street) for the time being until long-term plans are made.

[3] The City of Ithaca designated the station as a local landmark in January, 2019.

[4] Ithaca Bus Station was served by the following intercity bus lines: The station was on the Greyhound routes from New York City to Buffalo or Rochester daily, and from Syracuse to Elmira daily.