Ivane II Zakarian or Ivane II Mkhargrdzeli (Georgian: ივანე II მხარგრძელი; Armenian: Ավագ Բ Զաքարյան) was a 13th-century member of the Armenian Zakarid dynasty, and a Court official of the Kingdom of Georgia, holding the office of mandaturtukhutsesi (Mandator) of Georgia.
In 1260, David VII Ulu rebelled against its Mongol overlord.
Some of the nobles supported him, while most of them (Ivane Mkhargrdzeli, Grigol Surameli, Kakha Toreli etc.)
In 1262, David VII had to make peace with the Mongols and returned to Tbilisi, effectively splitting the country into two parts.
In 1288, Ivane fought campaign against Arghun Khan alongside Demetrius II.