Ivet Bahar is a Turkish-American computational biologist, currently serving as the Director of the Louis and Beatrice Laufer Center for Physical and Quantitative Biology, Louis & Beatrice Laufer Endowed Chair and Professor of Biochemistry and Cell Biology at the Stony Brook University, School of Medicine.
ENMs have three strengths: simplicity, ability to yield a unique solution for each structure, and efficient applicability to supramolecular complexes/assemblies.
Her theory and methods have withstood numerous tests since their inception, and established fundamental concepts in molecular biology: the role of entropy-driven fluctuations defined by 3D contact topology in optimizing biomolecular interactions; the evolutionary pressure for robustly maintaining structural dynamics to support flexible mechanisms of actions – not only structure to ensure stability; the ability of proteins to exploit their structure-encoded dynamics to adapt to promiscuous interactions and mutations as demonstrated in numerous applications, including neurotransmitter transporters in recent years.
Recent application to chromosomal dynamics provided insights into the physical basis of gene co-expression and regulation events.
[2] In 2016, she was invited by President Barack Obama as a guest speaker to the White House to give a talk on "Exascale Computing for Multiscale Modeling and Big Data in Biology.