In 1936, Husrieh allied himself with Abd al-Rahman Shahbandar, leader of the Syrian opposition to the National Bloc regime of President Hashim al-Atassi.

Shahbandar and Husrieh spoke out against the Franco-Syrian Treaty that Atassi had signed in Paris in 1936 that promised Syrian independence from France over a 25-year period.

Husrieh argued that the National Bloc had given too many concessions to the French, including the right to maintain military bases in Syria for use in the event of war in Europe.

Husrieh retaliated by issuing a secret pamphlet entitled al-Istifham(Question mark) that criticized the National Bloc and its entire leadership, accusing them of establishing a dictatorship in Syria.

When Syria and Egypt merged to form the United Arab Republic (UAR) in February 1958, he criticized the government of President Gamal Abdel Nasser and hailed the coup that ousted the union in September 1961.