Located at 236 East Washington Street in downtown Greensboro, it serves Amtrak passenger rail and is the city's main hub for local and intercity buses.

It was a replacement for an 1899 Southern Railway Depot that still exists today, albeit without the gabled-third story and cupola it had in the past.

[4] Designed by the New York architectural firm of Alfred T. Fellheimer & Steward Wagner, the 1927 Beaux-Arts facade of the Greensboro station features Ionic columns, a full entablature, and a three-story arched entry.

[6][7] The train station (lower level) is operated by Amtrak, providing inter-city rail service via three routes: Crescent, Carolinian and Piedmont.

The station is open 24-hours and includes a ticket office, passenger assistance, baggage service and waiting area.

Bus connections from other operators include the Piedmont Authority for Regional Transportation (PART) and Sunway Charters (Mountaineer Express East-West and Triad-Danville Connector).