[1] It was established in 1908 as the Archives of Internal Medicine and obtained its current title in 2013.

It covers all aspects of internal medicine, including cardiovascular disease, geriatrics, infectious disease, gastroenterology, endocrinology, allergy, and immunology.

Sharon K. Inouye of Harvard Medical School and Beth Israel Deaconess Hospital became the journal editor-in-chief on July 1, 2023, succeeding Rita F. Redberg of the University of California, San Francisco.

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