Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres.

Homo sapiens JTB (hJTB) encodes a transmembrane protein that is highly conserved among divergent eukaryotic species.

JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the transmembrane domain.

hJTB is located in a gene-rich region at 1q21, called epidermal differentiation complex (EDC).

[5] JTB has also been implicated in prostatic carcinomas.