His first feature film was The Disappearance of Alice Creed (2009), a thriller starring Gemma Arterton, Martin Compston, and Eddie Marsan, which he wrote and directed.

[4] Outside studying, he oversaw the writing and direction of two low-budget short films, Struggling (1997) and Red Tape (1998).

Chloë Grace Moretz played Cassie, and Susannah Grant wrote the screenplay.

[7] Blakeson directed the miniseries Gunpowder starring Kit Harington, Liv Tyler, Mark Gatiss, Peter Mullan and Shaun Dooley.

It was shown on BBC One in the UK and on HBO in the U.S.[8] Blakeson's next feature film was I Care a Lot, which was released on Netflix in 2021 and featured a Golden Globe Award-winning lead performance from Rosamund Pike.