The company was originally founded as a professional League of Legends team by Jack and Paullie Etienne in May 2013 and was incorporated into Cloud9 Esports, Inc. on September 6, 2016.

Cloud9 has received US$78 million in total raised equity via venture capital funding and was ranked the world's fifth-most valuable esports organization in mid-2022.

[9] In 2014, Cloud9 created divisions for Dota 2,[10] Super Smash Bros. Melee,[11] Hearthstone,[12] Counter-Strike: Global Offensive,[13] Heroes of the Storm,[14] and Halo.

[28] In the middle of that deal, Jack Etienne invited 30 investors to a London Spitfire match at Blizzard Arena; four months later, Cloud9 announced that it had received US$50 million in series B funding in a round led by Valor Equity Partners, along with other investors TrueBridge Capital Partners, Reimagined Ventures, and Glassdoor founder Robert Hohman.

[8][23] Funding from the round was to be used to establish a 20,000–30,000 square foot (1,900–2,800 m2) headquarters and training facility in Los Angeles, which was expected to be completed by the end of 2019.

[78] In the Summer playoffs, Cloud9 defeated Team SoloMid 3–2 to claim a spot at the 2021 League of Legends World Championship;[79] however, they lost their next match to 100 Thieves.

[121][122] On March 31, 2018, Mang0's coach Tafokints announced he was departing the organization to join Counter Logic Gaming as their business development manager.

Cloud9 entered the professional Counter-Strike: Global Offensive scene on August 1, 2014, with the acquisition of compLexity Gaming's North American roster.

[145] On October 30, Cloud9 defeated SK Gaming 2–1 in a best-of-three series to win the ESL Pro League Season 4 finals in São Paulo, Brazil.

[148][149] On March 31, Cloud9's main AWPer, Tyler "Skadoodle" Latham, announced on Twitter that he was taking a break from professional play.

[152] Cloud9 announced on December 6, 2019, that Timothy "autimatic" Ta, Damian "daps" Steele, and Kenneth "koosta" Suen had been released from the organization and their contracts bought out by Gen.G Esports.

[170] Cloud9 underwent more roster changes on July 13 of the same year, when buster and nafany were benched and replaced with former Natus Vincere players Denis "electronic" Sharipov and Ilya "Perfecto" Zalutskiy.

[173] At the tournament, the team lost to Fnatic in the opening round,[174] before achieving victories over 9INE, Monte and GamerLegion to secure play-offs.

[184] In the same month, Cloud9 Blue sign players Nathan "leaf" Orf from Chaos Esports Club's CS:GO division, and Son "xeta" Seon-ho from their former Korean team "Cloud9 Korea", as well as head coach Yoon "Autumn" Eu-teum and Manager Robin Lee.

[198] In VCT NA Stage 1: Challengers, Cloud9 narrowly missed out on Masters Reykjavik, placing third after losing to The Guard 0-3 in the lower final.

They announced their new roster consisting of core members vanity, leaf, and Xeppaa, and acquired Jordan "Zellsis" Montemurro who recently competed under Sentinels, OpTic Gaming superstar Jaccob "yay" Whiteaker, head coach Matthew "mCe" Elmore, and Mateja "qpert" Mijovic as substitute.

In the onset of VCT 2023: LOCK//IN, Cloud9 began the season with a dominant win against Paper Rex but, to the shock of many, fell short to DRX in their subsequent match, eliminating them as a result.

On September 29, 2023, Cloud9 announced vanity, OXY, wippie, and head coach Immi to the starting roster, who would join existing members jakee and Xeppaa.

[200] Cloud9 would compete in various OFF//SEASON tournaments prior to the start of 2024, including the TEN Global Invitational in Busan, in which they emerged victorious, and Red Bull Home Ground #4 in Tokyo, in which they lost 2-3 to FNATIC in the grand finals (albeit with curry as a stand-in to replace wippie).

Moving into the 2024 season, a poor performance in the inaugural Americas Kickoff tournament led to Cloud9's decision to release wippie and jakee.

On March 30, 2024, Cloud9 announced the re-signing of runi as well as the signing of Kaleb "moose" Jayne, who would join the roster for VCT Americas: Stage 1 onward.

In January and February 2021, Cloud9 White would fail to qualify for the VCT 2021: North America Stage 1 Challengers 1, 2 and 3 Main Events.

[24] With a roster consisting of players Kyle "Torment" Storer, Mariano "SquishyMuffinz" Arruda, and Jesus "Gimmick" Parra, the team began play in the North America Rocket League Championship Series (RLCS) Season 4.

[216] Cloud9 took down the defending champions by a series score of 4–1, marking the first time that a North American team had won the RLCS World Championship since Season 1.

[221] On June 10, 2020, Cloud9 would disband their Rocket League division [222] and wouldn't come back until April 18, 2024, where they would acquire a roster consisting of Hunter "LionBlaze" Woitas, Kadin "Zineel" Zineelabidine and Oliver "percy."

[19] The team won several LAN events in April and May, such as the One Nation of Gamers Overwatch Invitational, Overkill, and the Alienware Monthly Melee.

[225] Following Agents Rising, they finished second in both the June Alienware Monthly and Operation Breakout tournaments; both times they fell to Team EnVyUs in the finals.

[232] Meanwhile, Cloud9 KongDoo had been competing in OGN Overwatch APEX Season 4, where they ended up taking third place after defeating NC Foxes on October 17.

[242] London faced the Philadelphia Fusion in the Grand Finals on July 27 and 28; in the best-of-three series, the Spitfire won the first two matches by scores of 3–1 and 3–0 to claim the inaugural Overwatch League title.

[248] London defeated the Shanghai Dragons, 4–3, in the play-in tournament in an OWL record eight-map series and qualified for the season playoffs.